This Phase I project explored the use of arthrospira platensis (spirulina) based photobioreactors integrated into HVAC systems for indoor air purification. Major outcomes included the successful development and operational deployment of sealed photobioreactor systems, validation of gas reduction methodologies, and the integration of BACnet-based HVAC communication. Preliminary results demonstrate promising CO₂ reduction from 5000 ppm to 1000 ppm in 15 minutes with reductions measured in NO₂, and successful simulation of commercial HVAC controls with integration into the photobioreactor system. This research enables a scalable, low-energy air purification solution for commercial buildings, particularly in healthcare, office, and institutional settings, offering measurable pollutant reduction and energy savings while integrating seamlessly with existing HVAC infrastructure.